Continuous intrathecal baclofen infusions induced a marked increase of the transcranially evoked silent period in a patient with generalized dystonia

Muscle Nerve. 1998 Sep;21(9):1209-12. doi: 10.1002/(sici)1097-4598(199809)21:9<1209::aid-mus15>;2-m.


We observed a marked prolongation of the transcranially evoked silent period during continuous intrathecal administration of high doses of the gamma-aminobutyric acid (GABA)B receptor agonist baclofen in a patient with generalized dystonia. Size of motor evoked potentials and central conduction time remained unchanged during intrathecal baclofen administration. The selective prolongation of the silent period during high-dose continuous intrathecal baclofen therapy supports the notion that GABA(B)-ergic intracortical interneurons play a part in the generation of the transcranially evoked silent period.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Baclofen / administration & dosage*
  • Baclofen / therapeutic use
  • Dose-Response Relationship, Drug
  • Dystonia / drug therapy*
  • Dystonia / physiopathology*
  • Electromyography*
  • Evoked Potentials, Motor / physiology*
  • Humans
  • Injections, Spinal
  • Magnetics
  • Motor Cortex / physiology*
  • Physical Stimulation


  • Baclofen