Conduction velocity versus amplitude analysis: evidence for demyelination in diabetic neuropathy

Muscle Nerve. 1998 Sep;21(9):1228-30. doi: 10.1002/(sici)1097-4598(199809)21:9<1228::aid-mus20>;2-m.


Motor conduction velocities (CVs) were correlated with distal compound muscle action potential (CMAP) amplitudes for tibial, peroneal, and median nerves in patients with biopsy-proven chronic inflammatory demyelinating polyneuropathy (CIDP), diabetic neuropathy, and amyotrophic lateral sclerosis. Only in the diabetic patients did CV significantly correlate with CMAP amplitude. The data show that diabetic neuropathy produces conduction velocity slowing that cannot be explained by axon loss alone, and that differentiation between diabetic neuropathy and CIDP in an individual nerve is difficult.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Action Potentials / physiology
  • Adult
  • Aged
  • Amyotrophic Lateral Sclerosis / physiopathology
  • Demyelinating Diseases / physiopathology*
  • Diabetic Neuropathies / physiopathology*
  • Humans
  • Middle Aged
  • Muscle, Skeletal / physiopathology
  • Neural Conduction / physiology*
  • Peripheral Nervous System Diseases / physiopathology
  • Time Factors