Hepatic lesions of central pericellular fibrosis in morbid obesity, and after jejunoileal bypass

Am J Clin Pathol. 1976 Oct;66(4):684-91. doi: 10.1093/ajcp/66.4.684.


Histologic findings in liver biopsy specimens obtained from 88 patients before and one and two years after end-to-end jejunoileal bypass are compared. In addition to the expected fatty changes, mild changes of centrilobular, pericellular fibrosis were present in the initial biopsies in 8.6%; a year later they had become apparent in 46%. Portal-central bridging developed in 6.8%, and early micronodular cirrhosis in 3.4%--always in those with central pericellular fibrosis. Electron-microscopic study of pre-bypass liver biopsies from eight addtional patients showed collagen and electron-dense material resembling basement membranes within the spaces of Disse in seven, although only four had light-microscopic evidence of minimal central pericellular fibrosis. The existence of these light- and electron- microscopic changes before jejunoileal bypass suggests that there is a lesion in morbid obesity that may be exacerbated during the first year after operation.

MeSH terms

  • Fatty Acids / metabolism
  • Fatty Liver / etiology
  • Fatty Liver / pathology
  • Humans
  • Liver / metabolism
  • Liver / ultrastructure
  • Liver Cirrhosis / etiology
  • Liver Cirrhosis / pathology*
  • Obesity / complications
  • Obesity / pathology*
  • Obesity / therapy


  • Fatty Acids