Low-frequency mutation of Ha-ras and Ki-ras oncogenes in transitional cell carcinoma of the bladder

Anticancer Res. Jul-Aug 1998;18(4A):2675-8.


BACKGROUND, PATIENTS AND METHODS: The objective was to study the frequency of mutations of Ha-ras and Ki-ras oncogenes in bladder tumours. Transitional cell tumours of the bladder from 55 patients were subjected to analyses of Ha-ras and Ki-ras oncogenes using a variety of techniques including sequencing to detect mutations.

Results: Two tumours (4%) exhibited mutation of the Ki-ras oncogene, both tumours were fast growing and invasive. We did not detect Ha-ras mutation in any of the samples. Nineteen tumours (35%) with established invasion of the detrusor muscle, did not reveal any mutation.

Conclusion: Analyses of ras oncogenes seem to be of limited value for the biological assessment of transitional cell carcinomas.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Base Sequence
  • Carcinoma, Transitional Cell / genetics*
  • Carcinoma, Transitional Cell / pathology
  • Cell Division
  • Exons
  • Female
  • Genes, ras*
  • Humans
  • Male
  • Middle Aged
  • Mutation*
  • Neoplasm Invasiveness
  • Neoplasm Staging
  • Polymerase Chain Reaction
  • Urinary Bladder Neoplasms / genetics*
  • Urinary Bladder Neoplasms / pathology