Decline in sexual activities caused by diseases or by medication affecting the functions of the central nervous system has often been described, but there are few reports on diseases or medications causing hypersexuality. Bilateral lesions of the temporal lobes may result in the Klüver-Bucy syndrome, symptoms of which include hypersexuality, excessive eating, and mood changes. In this article, the authors describe moclobemide-induced reversible hypersexuality, without other features of the Klüver-Bucy syndrome, in two patients with stroke and one patient with Parkinson's disease.