Nef--an adaptor adaptor?

Trends Cell Biol. 1998 Aug;8(8):302-5. doi: 10.1016/s0962-8924(98)01318-x.


The Nef protein of human immunodeficiency virus (HIV) is a crucial factor in viral pathogenesis. One of the roles of this multifunctional protein is to decrease the cell-surface expression of CD4, a component of the virus receptor complex, and of MHC class I molecules. New results indicate that Nef can link CD4 to endocytic clathrin adaptor complexes and might also modulate other steps in the endocytic pathway.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • CD4 Antigens / metabolism
  • Endocytosis
  • Gene Products, nef / metabolism
  • Gene Products, nef / physiology*
  • Histocompatibility Antigens Class I / metabolism
  • Humans


  • CD4 Antigens
  • Gene Products, nef
  • Histocompatibility Antigens Class I