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Comparative Study
, 95 (3), 183-93

Subchronic Oral Toxicity of Turmeric and Ethanolic Turmeric Extract in Female Mice and Rats

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Comparative Study

Subchronic Oral Toxicity of Turmeric and Ethanolic Turmeric Extract in Female Mice and Rats

S S Deshpande et al. Toxicol Lett.

Abstract

Subchronic oral toxicity of turmeric and ethanolic turmeric extract was studied in female Swiss mice and Wistar rats fed turmeric (0, 1 and 5%) and ethanolic turmeric extract (0, 0.05 and 0.25%) through diet for 14 and/or 90 days. The administration of a high dose of turmeric (5%) for longer duration (90 days) showed a significant reduction in body weight gain, alterations in absolute and/or relative liver weights, and hepatotoxicity i.e. focal necrosis or focal necrosis with regeneration both in mice and rats. In mice lower doses of turmeric i.e 0.2 or 1% for 14 days also showed hepatotoxicity and they were found to be more vulnerable to turmeric-induced hepatotoxicity than rats.

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