RTI-113 administration reduces cocaine self-administration at high occupancy of dopamine transporter

Synapse. 1998 Sep;30(1):49-55. doi: 10.1002/(SICI)1098-2396(199809)30:1<49::AID-SYN6>3.0.CO;2-K.


RTI-113 [3beta-(4-chlorophenyl)tropan-2beta carboxylic acid phenyl ester hydrochloride], one of many phenyltropanes potent at and selective for DAT, inhibited self-administration of cocaine in rat at doses that did not alter responding maintained by food. The doses that inhibited cocaine intake produced significant levels of occupancy of DAT.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cocaine / administration & dosage*
  • Cocaine / analogs & derivatives*
  • Cocaine / pharmacology
  • Dose-Response Relationship, Drug
  • Extinction, Psychological
  • Male
  • Rats
  • Rats, Inbred F344
  • Reinforcement, Psychology
  • Self Administration*
  • Substance-Related Disorders / prevention & control*


  • RTI-113
  • Cocaine