Diabetic neuropathy

Med Clin North Am. 1998 Jul;82(4):909-29. doi: 10.1016/s0025-7125(05)70029-8.


Better clinical characteristics and a standardized approach to the definition of neuropathy has enabled us to define more precisely the natural history of diabetic neuropathy. Detailed studies on the pathology and pathogenesis have allowed dissection of important pathogenetic pathways. Effective treatment is currently limited, although a number of new and potentially important therapeutic interventions, including modification of the vascular supply and antioxidant status and growth factors, may prove to be of benefit in preventing damage and also promoting repair of peripheral nerves in human diabetic neuropathy.

Publication types

  • Review

MeSH terms

  • Antioxidants / therapeutic use
  • Diabetic Neuropathies / drug therapy
  • Diabetic Neuropathies / etiology*
  • Diabetic Neuropathies / pathology
  • Diabetic Neuropathies / physiopathology
  • Growth Substances / therapeutic use
  • Humans
  • Hypoglycemic Agents / therapeutic use
  • Nerve Fibers / pathology
  • Nerve Regeneration
  • Peripheral Nerves / blood supply
  • Peripheral Nerves / pathology
  • Peripheral Nerves / physiopathology


  • Antioxidants
  • Growth Substances
  • Hypoglycemic Agents