Cyclic AMP signaling and gene regulation

Annu Rev Nutr. 1998;18:353-83. doi: 10.1146/annurev.nutr.18.1.353.


Cyclic adenosine monophosphate (cAMP) is a ubiquitous second messenger produced in cells in response to hormones and nutrients. The production of cAMP is dependent upon the actions of many different proteins that affect its synthesis and degradation. An important function of cAMP is to activate the phosphorylating enzyme, protein kinase A. The key roles of cAMP and protein kinase A in the phosphorylation and regulation of enzyme substrates involved in intermediary metabolism are well known. A newly discovered role for protein kinase A is in the phosphorylation and activation of transcription factors that are critical for the control of the transcription of genes in response to elevated levels of cAMP.

Publication types

  • Review

MeSH terms

  • Animals
  • Cyclic AMP / metabolism*
  • Cyclic AMP Response Element-Binding Protein
  • Cyclic AMP-Dependent Protein Kinases / metabolism
  • Enzyme Activation
  • Gene Expression Regulation*
  • Humans
  • Signal Transduction*
  • Transcription Factors


  • Cyclic AMP Response Element-Binding Protein
  • Transcription Factors
  • Cyclic AMP
  • Cyclic AMP-Dependent Protein Kinases