A new method for plasma volume measurements with unlabeled dextran-70 instead of 125I-labeled albumin as an indicator

Clin Chim Acta. 1998 Jul 6;275(1):71-80. doi: 10.1016/s0009-8981(98)00080-1.


A method has been developed to determine plasma volume with dextran-70 without the use of a fluorescent label. The results obtained are compared to those found using the 125I-labeled albumin method, which is taken as the gold standard. The CV of the method is about 5%, compared to 3% with the gold standard. It is shown to be of use for the determination of an increase in plasma volume during pregnancy.

Publication types

  • Comparative Study

MeSH terms

  • Dextrans*
  • Female
  • Glucose
  • Humans
  • Indicator Dilution Techniques
  • Iodine Radioisotopes
  • Iodoproteins*
  • Plasma Volume*
  • Pregnancy
  • Sensitivity and Specificity
  • Serum Albumin*
  • Yeasts


  • Dextrans
  • Iodine Radioisotopes
  • Iodoproteins
  • Serum Albumin
  • Glucose