Helicobacter Pylori Infection and Gastric Neoplasia: Correlations With Histological Gastritis and Tumor Histology

Am J Gastroenterol. 1998 Aug;93(8):1271-6. doi: 10.1111/j.1572-0241.1998.00408.x.

Abstract

Objective: Several authors have reported an association between Helicobacter pylori (H. pylori) and gastric carcinoma, but the data are conflicting. Atrophic gastritis and intestinal metaplasia (IM) have also been linked to gastric carcinoma, especially the intestinal tumor type. We investigated the relationship between H. pylori infection, gastric neoplasms, and histological gastritis.

Methods: A total of 105 patients with gastric carcinoma, 36 patients with gastric adenoma, and 105 age- and sex-matched control subjects were examined for H. pylori infection and histological gastritis. H. pylori status was evaluated by Giemsa staining and IgG serology. Mucosal inflammation, atrophy, and IM were evaluated in biopsy specimens from antrum and corpus.

Results: H. pylori seroprevalence was higher in patients with gastric carcinoma (98 of 105, 93%) and adenoma (34 of 36, 94%) than in control subjects (82 of 105, 71%, p < 0.05). H. pylori was more prevalent in patients with noncardia (OR, 5.67; 95% CI, 2.25-14.44) than cardia (OR, 5.20; 95% CI, 0.65-41.68) tumors. Histologic types and tumor stage (early; OR, 6.60; 95% CI, 2.23-19.69, advanced; OR, 4.27; 95% CI, 1.21-15.03) showed no difference in H. pylori prevalence. Atrophy and IM scores were higher in patients with the intestinal- but not diffuse-type of carcinoma and adenoma than in H. pylori-positive control subjects. Smoking was associated with gastric carcinoma (OR, 3.05; 95% CI, 1.58-5.93) but not alcohol or coffee use, blood group A, or a family history of gastric cancer.

Conclusions: Our results confirm a strong association between H. pylori and gastric carcinoma and adenoma. The intestinal-type gastric carcinoma is associated with atrophic gastritis and IM.

Publication types

  • Comparative Study

MeSH terms

  • Adenoma / etiology
  • Adenoma / immunology
  • Adenoma / pathology*
  • Aged
  • Antibodies, Bacterial / blood
  • Biopsy
  • Carcinoma / etiology
  • Carcinoma / immunology
  • Carcinoma / pathology*
  • Case-Control Studies
  • Dyspepsia / complications
  • Dyspepsia / immunology
  • Dyspepsia / pathology
  • Female
  • Gastritis / complications
  • Gastritis / immunology
  • Gastritis / pathology*
  • Helicobacter Infections / complications
  • Helicobacter Infections / immunology
  • Helicobacter Infections / pathology*
  • Helicobacter pylori* / immunology
  • Helicobacter pylori* / isolation & purification
  • Humans
  • Male
  • Middle Aged
  • Risk Factors
  • Statistics as Topic
  • Stomach / microbiology
  • Stomach / pathology
  • Stomach Neoplasms / etiology
  • Stomach Neoplasms / immunology
  • Stomach Neoplasms / pathology*

Substances

  • Antibodies, Bacterial