Household aggregation of pulmonary function and chronic bronchitis

Am Rev Respir Dis. 1976 Sep;114(3):485-92. doi: 10.1164/arrd.1976.114.3.485.


Persons from 148 randomly selected households in an urban community were screened in their homes using a modified British Medical Research Council respiratory disease questionnaire and a portable spirometer. Analysis showed a significant tendency for chronic bronchitis to aggregate within households. Significant aggregation was observed for 1-sec forced expiratory volume, when measured as the per cent of the predicted value or as a score calculated from the data. The 1-sec forced expiratory volume was significantly correlated between siblings, but less clearly so between spouses. Correlation of 1-sec forced expiratory volume between mother and child appeared to be confounded by maternal smoking habits, an effect most notable between mothers and male offspring. The 1-sec forced expiratory volume of fathers was significantly correlated with that of their children, especially female children, an effect that appeared to be independent of smoking habits.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Airway Obstruction / epidemiology
  • Airway Obstruction / genetics
  • Boston
  • Bronchitis / epidemiology
  • Bronchitis / genetics*
  • Bronchitis / physiopathology
  • Child
  • Child, Preschool
  • Chronic Disease
  • Forced Expiratory Volume
  • Humans
  • Middle Aged
  • Sex Factors
  • Smoking
  • Statistics as Topic