Sudden cardiac death: a matter of faulty ion channels?

Curr Biol. 1998;8(16):R568-71. doi: 10.1016/s0960-9822(07)00363-6.

Abstract

Recent evidence suggests that various forms of sudden cardiac death in people with hearts that apparently function normally are caused by inherited or de novo mutations in genes coding for ion channel subunits.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Death, Sudden, Cardiac*
  • Heart / physiology
  • Heart / physiopathology
  • Humans
  • Ion Channels / genetics*
  • Ion Channels / physiology
  • Models, Cardiovascular
  • Molecular Sequence Data
  • Mutation
  • NAV1.5 Voltage-Gated Sodium Channel
  • Protein Structure, Secondary
  • Sodium Channels / chemistry
  • Sodium Channels / genetics

Substances

  • Ion Channels
  • NAV1.5 Voltage-Gated Sodium Channel
  • SCN5A protein, human
  • Sodium Channels