In vivo differentiation of astrocytic brain tumors and isolated demyelinating lesions of the type seen in multiple sclerosis using 1H magnetic resonance spectroscopic imaging

Ann Neurol. 1998 Aug;44(2):273-8. doi: 10.1002/ana.410440222.


We used computer pattern recognition of proton magnetic resonance spectroscopic image data to differentiate between brain tumors and large, isolated, demyelinating lesions of the type seen in multiple sclerosis. Leave-one-out linear discriminant analyses correctly classified resonance profiles from five acute demyelinating lesions, 20 low-grade astrocytomas, 22 anoplastic astrocytomas, and 24 glioblastomas. Classification of nonacute lesions will require further development, as the metabolic profiles of demyelinating lesions evolve over time.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Analysis of Variance
  • Astrocytes / metabolism
  • Astrocytes / pathology
  • Astrocytoma / diagnosis*
  • Astrocytoma / metabolism
  • Brain Neoplasms / diagnosis*
  • Brain Neoplasms / metabolism
  • Demyelinating Diseases / diagnosis*
  • Demyelinating Diseases / metabolism
  • Diagnosis, Differential
  • Female
  • Glioblastoma / diagnosis*
  • Glioblastoma / metabolism
  • Humans
  • Magnetic Resonance Spectroscopy*
  • Multiple Sclerosis / diagnosis
  • Multiple Sclerosis / metabolism