Links in the left/right axial pathway

Cell. 1998 Aug 7;94(3):273-6. doi: 10.1016/s0092-8674(00)81468-3.


We now have a sketch of the vertebrate L/R pathway from egg to organ. There is a lot to learn and a lot to explain, but the beauty of the pathway is already evident. We also have an inkling of its fragility. Set against the complex laterality disorders seen in humans, efforts to understand this pathway should continue to challenge our intellectual and experimental dexterity.

Publication types

  • Review

MeSH terms

  • Animals
  • Body Patterning / genetics
  • Body Patterning / physiology*
  • Gene Expression Regulation, Developmental / physiology
  • Humans