Pitx2 participates in the late phase of the pathway controlling left-right asymmetry

Cell. 1998 Aug 7;94(3):319-24. doi: 10.1016/s0092-8674(00)81475-0.

Abstract

Pitx2, a member of the bicoid-related family of homeobox-containing genes, is asymmetrically expressed in the left lateral plate mesoderm and derived tissues during chick and mouse development. Modifications of Pitx2 pattern of expression in the iv mouse mutation correlate with the situs alterations characteristic of the mutation. Misexpression experiments demonstrate that Shh and nodal positively regulate Pitx2 expression. Our results are compatible with a Pitx2 function in the late phase of the gene cascade controlling laterality.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Body Patterning / genetics*
  • Chick Embryo
  • Conserved Sequence
  • Gene Expression Regulation, Developmental*
  • Homeodomain Proteins / biosynthesis
  • Homeodomain Proteins / genetics*
  • Homeodomain Proteins / physiology*
  • Mesoderm / pathology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Mutant Strains
  • Mutation
  • Nodal Protein
  • Nuclear Proteins*
  • Paired Box Transcription Factors
  • Proteins / genetics
  • Proteins / physiology
  • Signal Transduction / genetics*
  • Situs Inversus / genetics
  • Transcription Factors / biosynthesis
  • Transcription Factors / genetics*
  • Transcription Factors / physiology*
  • Transforming Growth Factor beta*

Substances

  • Homeodomain Proteins
  • Nodal Protein
  • Nodal protein, mouse
  • Nuclear Proteins
  • Paired Box Transcription Factors
  • Proteins
  • Transcription Factors
  • Transforming Growth Factor beta
  • homeobox protein PITX1
  • homeobox protein PITX3
  • homeobox protein PITX2