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. 1998 Aug 7;94(3):363-74.
doi: 10.1016/s0092-8674(00)81479-8.

The Novel ATM-related Protein TRRAP Is an Essential Cofactor for the c-Myc and E2F Oncoproteins

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The Novel ATM-related Protein TRRAP Is an Essential Cofactor for the c-Myc and E2F Oncoproteins

S B McMahon et al. Cell. .
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Abstract

The c-Myc and E2F transcription factors are among the most potent regulators of cell cycle progression in higher eukaryotes. This report describes the isolation of a novel, highly conserved 434 kDa protein, designated TRRAP, which interacts specifically with the c-Myc N terminus and has homology to the ATM/PI3-kinase family. TRRAP also interacts specifically with the E2F-1 transactivation domain. Expression of transdominant mutants of the TRRAP protein or antisense RNA blocks c-Myc- and E1A-mediated oncogenic transformation. These data suggest that TRRAP is an essential cofactor for both the c-Myc and E1A/E2F oncogenic transcription factor pathways.

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