Antioxidant protection of cerebellar beta-adrenergic receptor function in aged F344 rats

Neurosci Lett. 1998 Jul 10;250(3):165-8. doi: 10.1016/s0304-3940(98)00477-7.


We examined whether a 2-week treatment with the spin-trapping agent MDL 101.002 (MDL) or a diet supplemented with vitamin E (Vit E) would alleviate age-related deficits in cerebellar noradrenergic function of male 18-20 month old F344 rats compared to age-matched controls. Cerebellar beta-adrenergic receptor function was assessed using extracellular recordings of Purkinje cells during iontophoresis of GABA and isoproterenol (ISO). Noradrenergic receptor function of MDL and Vit E-treated rats was similar to young rats whereas for non-treated rats it was typical of that previously recorded in aged rats. Thus, treatment with MDL or Vit E reverses age-related deficits in cerebellar noradrenergic receptor function.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Age Factors
  • Animals
  • Antioxidants / metabolism*
  • Cerebellum / metabolism*
  • Male
  • Rats
  • Rats, Inbred F344
  • Receptors, Adrenergic, beta / physiology*


  • Antioxidants
  • Receptors, Adrenergic, beta