CH domains revisited

FEBS Lett. 1998 Jul 17;431(2):134-7. doi: 10.1016/s0014-5793(98)00751-0.


A sequence motif of about 100 amino acids, termed the 'calponin homology domain' has been suggested to confer actin binding to a variety of cytoskeletal and signalling molecules. Here we analyse and compare the sequences of all calponin homology domain-containing proteins identified to date. We propose that single calponin homology domains do not confer actin-binding per se and that the actin-binding motifs of cross-linking proteins, which comprise two disparate calponin homology domains, represent a unique protein module.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actins / metabolism*
  • Amino Acid Sequence
  • Animals
  • Calcium-Binding Proteins / chemistry*
  • Calcium-Binding Proteins / metabolism
  • Databases, Factual
  • Humans
  • Microfilament Proteins
  • Molecular Sequence Data
  • Phylogeny
  • Protein Conformation
  • Sequence Homology, Amino Acid


  • Actins
  • Calcium-Binding Proteins
  • Microfilament Proteins
  • calponin