Peribulbar anaesthesia using a mixture of local anaesthetic and vecuronium

Anaesthesia. 1998 Jun;53(6):551-4. doi: 10.1046/j.1365-2044.1998.00433.x.

Abstract

The aim of this double-blind, randomised study was to assess the effects of the addition of 0.5 mg of vecuronium bromide to a standard local anaesthetic mixture used for peribulbar anaesthesia. We studied 60 patients undergoing regional anaesthesia for intra-ocular surgery and were primarily interested in the quality of globe and lid akinesia. All received a mixture of 5 ml 2% lignocaine with 1:200,000 adrenaline, 5 ml 0.75% bupivacaine and 150 IU hyaluronidase with either 0.9% saline 0.25 ml (group A, n = 30) or vecuronium bromide 0.25 ml (0.5 mg) (group B, n = 30). Eye movements assessed at both 5 and 10 min were significantly reduced in the vecuronium group (group B) (p < 0.05). We conclude that the addition of vecuronium at a dose of 0.5 mg to the standard local anaesthetic mixture improves the quality of globe and lid akinesia.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Aged, 80 and over
  • Anesthesia, Conduction / methods*
  • Anesthetics, Combined
  • Anesthetics, Local*
  • Bupivacaine
  • Double-Blind Method
  • Eye Movements / drug effects
  • Female
  • Humans
  • Lidocaine
  • Male
  • Neuromuscular Nondepolarizing Agents*
  • Ophthalmologic Surgical Procedures*
  • Vecuronium Bromide*

Substances

  • Anesthetics, Combined
  • Anesthetics, Local
  • Neuromuscular Nondepolarizing Agents
  • Vecuronium Bromide
  • Lidocaine
  • Bupivacaine