Incidence and risk factors of catheter-related deep vein thrombosis in a pediatric intensive care unit: a prospective study

J Pediatr. 1998 Aug;133(2):237-41. doi: 10.1016/s0022-3476(98)70226-4.


Objective: To estimate the incidence and to characterize risk factors for central venous catheter (CVC)-related deep vein thrombosis (DVT) in a pediatric intensive care unit.

Study design: Consecutive children admitted to a pediatric intensive care unit who required a CVC for more than 48 hours were examined by Doppler ultrasonography of the catheterized vein at days 2, 4, 6, or 7 after insertion and weekly thereafter until CVC removal.

Results: The incidence of CVC-related DVT was 18.3% (17 of 93) (95% confidence interval = 10.2% to 25.8%). Thromboses were diagnosed within the first 4 days of catheter placement for 15 of 17 CVC-related thromboses. Multivariate analysis showed that risk factors most predictive of CVC-related DVT were presence of a cancer (odds ratio = 17.23, 95% confidence interval = 1.5 to 194) and young age (odds ratio for age = 0.72, 95% confidence interval = 0.54 to 0.96).

Conclusion: The frequency of CVC-related DVT is substantial in pediatric intensive care units. Risk is highest during the 4 days after insertion and decreases thereafter. The clinical impact, optimal prevention, and therapy of these thromboses remain to be determined.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catheterization, Central Venous* / adverse effects
  • Child
  • Child, Preschool
  • Humans
  • Incidence
  • Infant
  • Intensive Care Units, Pediatric / statistics & numerical data
  • Multivariate Analysis
  • Prospective Studies
  • Quebec
  • Risk Factors
  • Thrombosis / diagnostic imaging
  • Thrombosis / epidemiology*
  • Ultrasonography