Monoclonal antibodies to CD4

Rheum Dis Clin North Am. 1998 Aug;24(3):567-78. doi: 10.1016/s0889-857x(05)70026-0.


Animal models of human autoimmune disease suggest that it should be possible to reinduce self-tolerance in these conditions by the use of T-cell directed therapies, in particular with anti-CD4 monoclonal antibodies (CD4-mAb). Many studies have shown that CD4-mAb can prevent and in a treatment setting suppress activity of these disease models, including collagen-induced arthritis.

Publication types

  • Review

MeSH terms

  • Animals
  • Antibodies, Monoclonal / therapeutic use*
  • Arthritis, Rheumatoid / immunology*
  • Arthritis, Rheumatoid / therapy
  • CD4 Antigens / immunology*
  • CD4-Positive T-Lymphocytes / immunology*
  • Disease Models, Animal
  • Humans
  • Inflammation / immunology
  • Mice
  • Rats


  • Antibodies, Monoclonal
  • CD4 Antigens