Interleukin-1 receptor antagonist

Rheum Dis Clin North Am. 1998 Aug;24(3):615-28. doi: 10.1016/s0889-857x(05)70029-6.


There are three members of the IL-1 gene family: IL-1 alpha, IL-1 beta, and IL-1ra, IL-1 alpha, and IL-1 beta are both antagonist molecules with many proinflammatory effects. IL-1ra is an antagonist molecule that can inhibit the effect of IL-1 alpha and IL-1 beta by specifically blocking the IL-1 receptor on target effector cells. IL-1 alpha and IL-1 beta are considered to be pivotal cytokines in the pathogenesis of many inflammatory diseases. Anti-IL-1 treatment has been shown to cause amelioration of arthritis in animal models and in RA, suggesting that IL-1ra may be an important therapeutic option in the future management of RA.

Publication types

  • Review

MeSH terms

  • Arthritis, Rheumatoid / immunology
  • Arthritis, Rheumatoid / physiopathology
  • Arthritis, Rheumatoid / therapy*
  • Disease Models, Animal
  • Humans
  • Inflammation / immunology
  • Interleukin-1 / pharmacology
  • Receptors, Interleukin-1 / antagonists & inhibitors*
  • Receptors, Interleukin-1 / therapeutic use


  • Interleukin-1
  • Receptors, Interleukin-1