The ARF family of transcription factors and their role in plant hormone-responsive transcription

Cell Mol Life Sci. 1998 Jul;54(7):619-27. doi: 10.1007/s000180050190.

Abstract

Auxin response factors or ARFs are a recently discovered family of transcription factors that bind with specificity to auxin response elements (AuxREs) in promoters of primary or early auxin-responsive genes. ARFs have an amino-terminal DNA-binding domain related to the carboxyl-terminal DNA-binding domain in the maize transactivator VIVIPAROUS1. All but one ARF identified to date contain a carboxyl-terminal protein-protein interaction domain that forms a putative amphipathic alpha-helix. A similar carboxyl-terminal protein-protein interaction domain is found in the Aux/IAA class of auxin-inducible proteins. Some ARFs contain transcriptional activation domains, while others contain repression domains. ARFs appear to play a pivotal role in auxin-regulated gene expression of primary response genes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Arabidopsis / physiology
  • DNA-Binding Proteins / chemistry
  • Gene Expression Regulation, Plant / drug effects
  • Indoleacetic Acids / pharmacology
  • Plant Growth Regulators / pharmacology*
  • Plant Proteins / chemistry*
  • Promoter Regions, Genetic / genetics
  • Protein Structure, Secondary
  • Transcription Factors / chemistry*

Substances

  • DNA-Binding Proteins
  • Indoleacetic Acids
  • Plant Growth Regulators
  • Plant Proteins
  • Transcription Factors