UK-3A, a novel antifungal antibiotic from Streptomyces sp. 517-02: fermentation, isolation, structural elucidation and biological properties

J Antibiot (Tokyo). 1997 Jul;50(7):551-5. doi: 10.7164/antibiotics.50.551.

Abstract

A novel antifungal antibiotic, UK-3A, was obtained from the mycelial cake of Streptomyces sp. 517-02. UK-3A was very similar in structure to UK-2A, a structural relative of antimycin A. The antifungal spectrum of UK-3A was relatively broad (MICs for yeasts and filamentous fungi: 1.56-6.25 and 0.39-1.56 micrograms/ml, respectively). The cytotoxic activity of UK-3A was weak (IC50: 18-100 micrograms/ml).

MeSH terms

  • Antibiotics, Antineoplastic / chemistry
  • Antibiotics, Antineoplastic / pharmacology
  • Antifungal Agents / chemistry*
  • Antifungal Agents / isolation & purification
  • Antifungal Agents / pharmacology*
  • Chromatography, High Pressure Liquid
  • Fermentation
  • Humans
  • In Vitro Techniques
  • Lactones / chemistry*
  • Lactones / isolation & purification
  • Lactones / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Pyridines / chemistry*
  • Pyridines / isolation & purification
  • Pyridines / pharmacology*
  • Streptomyces / classification
  • Streptomyces / metabolism*
  • Tumor Cells, Cultured / drug effects

Substances

  • Antibiotics, Antineoplastic
  • Antifungal Agents
  • Lactones
  • Pyridines
  • UK-3A