Mania associated with codeine and paracetamol

Aust N Z J Psychiatry. 1998 Aug;32(4):586-8. doi: 10.3109/00048679809068336.


Objective: We describe a patient in whom a manic episode was precipitated by use of panadeine forte, a preparation containing codeine and paracetamol.

Clinical picture: The patient developed a discrete manic psychotic episode.

Treatment: The treatment consisted of cessation of the Panadeine forte and antipsychotic medication.

Outcome: The patient made a complete recovery after 1 week.

Conclusions: Mania can be induced by large doses of Panadeine forte, particularly if there is a biological predisposition.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetaminophen / adverse effects*
  • Analgesics, Non-Narcotic / adverse effects*
  • Analgesics, Opioid / adverse effects*
  • Bipolar Disorder / chemically induced*
  • Codeine / adverse effects*
  • Drug Combinations
  • Humans
  • Low Back Pain / drug therapy
  • Male
  • Middle Aged


  • Analgesics, Non-Narcotic
  • Analgesics, Opioid
  • Drug Combinations
  • Acetaminophen
  • Codeine