Effects of therapeutic stimulation of nucleus caudatus on epileptic electrical activity of brain in patients with intractable epilepsy

Stereotact Funct Neurosurg. 1997;69(1-4 Pt 2):221-4. doi: 10.1159/000099878.


The effects of electrostimulation of caput nuclei caudati (CNC) were investigated in 57 patients. Long-term implanted multicontact electrodes were used in 38 patients. In 23 cases, completely implanted neurostimulators and in the remaining 15 cases externalized electrodes were used. Investigations demonstrated that a low-frequency (4-6 Hz) stimulation of certain points of the ventral part of CNC reliably led to (1) a decrease of interparoxysmal activity in the neocortical and mesial temporal epileptic foci; (2) a decrease of focal discharges in the aforementioned areas, and (3) abrupt cessation of spreading and generalized discharge.

MeSH terms

  • Amygdala / physiology
  • Caudate Nucleus / physiology*
  • Electric Stimulation Therapy*
  • Electrodes, Implanted
  • Electroencephalography
  • Epilepsy / therapy*
  • Functional Laterality / physiology
  • Hippocampus / physiology
  • Humans
  • Stereotaxic Techniques
  • Treatment Outcome