Elevated Concentrations of Eotaxin and interleukin-5 in Human Neurocysticercosis

Infect Immun. 1998 Sep;66(9):4522-5.

Abstract

Symptomatic neurocysticercosis, a major cause of epilepsy worldwide, results from inflammation around Taenia solium larvae, but the mechanisms are unknown. Eotaxin, not previously reported in cases of human infection, and interleukin-5 (IL-5) but not IL-8 concentrations were elevated in patient serum, and IL-5 levels were also elevated in cerebrospinal fluid (CSF). Eosinophil-selective mediators may be involved in the pathogenesis of cysticercosis. IL-6 concentrations were also elevated in patient CSF, possibly indicative of an acute-phase response.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Animals
  • Chemokine CCL11
  • Chemokines, CC*
  • Chemotactic Factors, Eosinophil / metabolism*
  • Cysticercosis / blood
  • Cysticercosis / cerebrospinal fluid
  • Cysticercosis / immunology*
  • Cytokines / blood
  • Cytokines / cerebrospinal fluid
  • Cytokines / metabolism*
  • Humans
  • Interleukin-5 / metabolism*
  • Middle Aged
  • Taenia / immunology*

Substances

  • CCL11 protein, human
  • Chemokine CCL11
  • Chemokines, CC
  • Chemotactic Factors, Eosinophil
  • Cytokines
  • Interleukin-5