Kinetics of Chlamydia trachomatis clearance in patients with azithromycin, as assessed by first void urine testing by PCR and transcription-mediated amplification

Sex Transm Dis. 1998 Aug;25(7):366-7. doi: 10.1097/00007435-199808000-00008.


Methods: Test-of-cure of 19 patients with Chlamydia trachomatis genital infection was assessed by daily collection of first void urine for 7 days just after treatment by azithromycin single-dose.

Results: Detection by PCR and TMA of C. trachomatis showed a good correlation between both methods. The observation that post-therapy chlamydial nucleic acid detection is associated to bacterial clearance suggests that all the patients were cured.

MeSH terms

  • Anti-Bacterial Agents / therapeutic use*
  • Azithromycin / therapeutic use*
  • Chlamydia Infections / drug therapy*
  • Chlamydia Infections / microbiology
  • Chlamydia Infections / urine
  • Chlamydia trachomatis*
  • DNA, Bacterial / urine
  • Female
  • Follow-Up Studies
  • Gene Amplification
  • Humans
  • Male
  • Polymerase Chain Reaction
  • Transcription, Genetic


  • Anti-Bacterial Agents
  • DNA, Bacterial
  • Azithromycin