Inhibitory effect of curcuminoids on MCF-7 cell proliferation and structure-activity relationships

Cancer Lett. 1998 Jul 3;129(1):111-6. doi: 10.1016/s0304-3835(98)00092-5.


Curcumin, demethoxycurcumin and bisdemethoxycurcumin are the yellow coloring phenolic compounds isolated from the spice turmeric. This study was part of a program correlating the biological activity and molecular structure of antitumor agents; the effect of these curcuminoids and cyclocurcumin (Cyclocur) was examined on the proliferation of MCF-7 human breast tumor cells. Curcuminoids appeared to be potent inhibitors, whereas Cyclocur was less inhibitory. To contribute to our understanding of the mechanism of antiproliferative activity of curcumin, cell cycle analysis was performed by propidium iodide staining and a flow cytometry technique. Curcumin exerts a cytostatic effect at G2/M which explains its antiproliferative activity. The presence of the diketone moiety in the curcumin molecule seems to be essential for the inhibitory activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anticarcinogenic Agents / chemistry
  • Anticarcinogenic Agents / pharmacology*
  • Breast Neoplasms / pathology
  • Cell Cycle / drug effects
  • Cell Division / drug effects*
  • Coumaric Acids / chemistry
  • Coumaric Acids / pharmacology*
  • Curcumin / analogs & derivatives*
  • Curcumin / chemistry
  • Curcumin / pharmacology*
  • Diarylheptanoids
  • Humans
  • Structure-Activity Relationship
  • Tumor Cells, Cultured


  • Anticarcinogenic Agents
  • Coumaric Acids
  • Diarylheptanoids
  • bis(4-hydroxycinnamoyl)methane
  • Curcumin
  • demethoxycurcumin