Dissociation between genes activated in long-term potentiation and in spatial learning in the rat

Neurosci Lett. 1998 Jul 17;251(1):41-4. doi: 10.1016/s0304-3940(98)00476-5.


We have compared changes in mRNA of three genes, zif268, raf B, and syntaxin 1 B, following the unilateral induction of long-term potentiation (LTP) in rats previously trained in a water maze, and in behaviourally naive animals. mRNA of all three genes was enhanced in the potentiated dentate gyrus of naive animals 3 h after the induction of LTP. Training did not affect expression of mRNA for zif268 or for syntaxin 1 B. Expression of raf B was enhanced by training, and in trained animals the LTP-associated increase in expression of raf B was occluded. These results suggest that LTP and spatial training engage a common pathway utilizing an increase in mRNA for raf B, and demonstrate a dissociation between LTP and spatial learning with respect to expression of zif268 and syntaxin 1B.

MeSH terms

  • Animals
  • Antigens, Surface / genetics
  • Brain / metabolism*
  • DNA-Binding Proteins / genetics
  • Early Growth Response Protein 1
  • Functional Laterality
  • Gene Expression Regulation*
  • Immediate-Early Proteins*
  • Long-Term Potentiation / physiology*
  • Maze Learning / physiology*
  • Nerve Tissue Proteins / genetics
  • Proto-Oncogene Proteins c-raf / genetics
  • RNA, Messenger / genetics
  • Rats
  • Space Perception
  • Syntaxin 1
  • Transcription Factors / genetics
  • Transcription, Genetic
  • Zinc Fingers


  • Antigens, Surface
  • DNA-Binding Proteins
  • Early Growth Response Protein 1
  • Egr1 protein, rat
  • Immediate-Early Proteins
  • Nerve Tissue Proteins
  • RNA, Messenger
  • Stx1a protein, rat
  • Syntaxin 1
  • Transcription Factors
  • Proto-Oncogene Proteins c-raf