Elevated levels of interleukin-6 may occur in cerebrospinal fluid from patients with recent epileptic seizures

Epilepsy Res. 1998 Jul;31(2):129-33. doi: 10.1016/s0920-1211(98)00024-2.


Experimental animal studies suggest the involvement of cytokines in epilepsy. We measured increased concentrations of interleukin-6 in four out of 15 cerebrospinal fluid samples from unmedicated patients with newly developed tonic-clonic seizures; plasma levels were also increased but to a lesser extent. Although the significance of cytokine production in relation to epileptic seizures is not known, it might be important for neuronal survival.

MeSH terms

  • Adolescent
  • Adult
  • C-Reactive Protein / cerebrospinal fluid
  • Female
  • Humans
  • Interleukin-6 / cerebrospinal fluid*
  • Male
  • Middle Aged
  • Seizures / cerebrospinal fluid*
  • Time Factors


  • Interleukin-6
  • C-Reactive Protein