RAP, a novel type of ER chaperone

G Bu; A L Schwartz

doi:10.1016/s0962-8924(98)01283-5

RAP, a novel type of ER chaperone

Trends Cell Biol. 1998 Jul;8(7):272-6. doi: 10.1016/s0962-8924(98)01283-5.

Authors

G Bu¹, A L Schwartz

Affiliation

¹ Dept of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA.

PMID: 9714598
DOI: 10.1016/s0962-8924(98)01283-5

Abstract

Members of the low-density lipoprotein (LDL) receptor gene family play an important role in cellular uptake of various extracellular ligands. Recent studies have shown that a 39-kDa protein known as RAP (receptor-associated protein) serves as a molecular chaperone to assist the folding of certain LDL-receptor family proteins and their passage through the secretory pathway. In this review, the authors discuss our current understanding of the roles of RAP as a molecular chaperone/escort protein and present a model of how RAP might carry out these functions.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Carrier Proteins / physiology*
Endoplasmic Reticulum / chemistry*
Endoplasmic Reticulum / physiology
Eukaryotic Cells / chemistry
Eukaryotic Cells / physiology
Glycoproteins / physiology*
Humans
LDL-Receptor Related Protein-Associated Protein
Molecular Chaperones / physiology*
Receptors, LDL / physiology

Substances

Carrier Proteins
Glycoproteins
LDL-Receptor Related Protein-Associated Protein
Molecular Chaperones
Receptors, LDL