FRG1, a gene in the FSH muscular dystrophy region on human chromosome 4q35, is highly conserved in vertebrates and invertebrates

Gene. 1998 Aug 17;216(1):13-9. doi: 10.1016/s0378-1119(98)00334-5.


The human FRG1 gene maps to human chromosome 4q35 and was identified as a candidate for facioscapulohumeral muscular dystrophy. However, FRG1 is apparently not causally associated with the disease and as yet, its function remains unclear. We have cloned homologues of FRG1 from two additional vertebrates, the mouse and the Japanese puffer fish Fugu rubripes, and investigated the genomic organization of the genes in the two species. The intron/exon structure of the genes is identical throughout the protein coding region, although the Fugu gene is five times smaller than the mouse gene. We have also identified FRG1 homologues in two nematodes; Caenorhabditis elegans and Brugia malayi. The FRG1 protein is highly conserved and contains a lipocalin sequence motif, suggesting it may function as a transport protein.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chromosomes, Human, Pair 4 / genetics*
  • Conserved Sequence / genetics*
  • Exons / genetics
  • Fishes, Poisonous / genetics
  • Genes / genetics*
  • Humans
  • Introns / genetics
  • Invertebrates / genetics*
  • Mice
  • Microfilament Proteins
  • Molecular Sequence Data
  • Muscular Dystrophies / genetics*
  • Nuclear Proteins
  • Proteins / genetics*
  • RNA-Binding Proteins
  • Sequence Alignment
  • Sequence Analysis, DNA
  • Sequence Homology, Amino Acid
  • Vertebrates / genetics*


  • FRG1 protein, human
  • Frg1 protein, mouse
  • Microfilament Proteins
  • Nuclear Proteins
  • Proteins
  • RNA-Binding Proteins

Associated data

  • GENBANK/AA283478
  • GENBANK/AA445904
  • GENBANK/AF042797
  • GENBANK/N41287