Rab proteins

Biochim Biophys Acta. 1998 Aug 14;1404(1-2):101-12. doi: 10.1016/s0167-4889(98)00050-0.

Abstract

Rab proteins form the largest branch of the Ras superfamily of GTPases. They are localized to the cytoplasmic face of organelles and vesicles involved in the biosynthetic/secretory and endocytic pathways in eukaryotic cells. It is now well established that Rab proteins play an essential role in the processes that underlie the targeting and fusion of transport vesicles with their appropriate acceptor membranes. However, the recent discovery of several putative Rab effectors, which are not related to each other and which fulfil diverse functions, suggests a more complex role for Rab proteins. At least two Rab proteins act at the level of the Golgi apparatus. Rab1 and its yeast counterpart Ypt1 control transport events through early Golgi compartments. Work from our laboratory points out a role for Rab6 in intra-Golgi transport, likely in a retrograde direction.

Publication types

  • Review

MeSH terms

  • Animals
  • Carrier Proteins / physiology
  • GTP Phosphohydrolases / physiology*
  • GTP-Binding Proteins / physiology
  • Golgi Apparatus / physiology*
  • Humans
  • Monomeric GTP-Binding Proteins*
  • Saccharomyces cerevisiae Proteins*
  • rab GTP-Binding Proteins*
  • ras Proteins / physiology*

Substances

  • Carrier Proteins
  • Rab6 protein
  • Saccharomyces cerevisiae Proteins
  • GTP Phosphohydrolases
  • GTP-Binding Proteins
  • YPT1 protein, S cerevisiae
  • Monomeric GTP-Binding Proteins
  • rab GTP-Binding Proteins
  • ras Proteins