Sequences and expression of six new members of the tetraspanin/TM4SF family

Biochim Biophys Acta. 1998 Jul 30;1399(1):101-4. doi: 10.1016/s0167-4781(98)00087-6.


Tetraspanins (or TM4SF) are expressed in a wide variety of species and regulate cell adhesion, migration, proliferation and differentiation. We have identified and sequenced six new members of the tetraspanin family, called Tspan-1-6, from human cDNA. Amino acid sequence analysis of the Tspans highlights conserved residues which may be critical to tetraspanin structure and function. The Tspans are differentially expressed in human tissues.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • DNA, Complementary / chemistry
  • DNA, Complementary / isolation & purification*
  • Gene Library
  • Humans
  • Membrane Proteins / chemistry
  • Membrane Proteins / genetics*
  • Molecular Sequence Data
  • Sequence Alignment
  • Sequence Homology, Amino Acid


  • DNA, Complementary
  • Membrane Proteins

Associated data

  • GENBANK/AF053453
  • GENBANK/AF053454
  • GENBANK/AF053455
  • GENBANK/AF054838
  • GENBANK/AF054839
  • GENBANK/AF054840
  • GENBANK/AF054841