Optical cross-sectional imaging of the macula with the retinal thickness analyzer in X-linked retinoschisis

Arch Ophthalmol. 1998 Aug;116(8):1036-41. doi: 10.1001/archopht.116.8.1036.


Objective: To assess the morphologic characteristics of the foveal abnormality in juvenile X-linked retinoschisis using the scanning retinal thickness analyzer (RTA). This characteristic foveal abnormality is present in 83% to 100% of patients with X-linked retinoschisis and has not been demonstrated histopathologically.

Methods: The RTA is a noncontact imaging device. The RTA scans an obliquely oriented slit laser beam across the macula to obtain a series of optical cross sections, which are digitized.

Participants: The RTA was used to examine 7 eyes of 5 patients with X-linked retinoschisis.

Results: The RTA demonstrated foveal schisis in all eyes examined. In 2 eyes of 2 patients, a single schisis cavity, with an inner leaf in a dome-shaped configuration, was present. In 4 eyes of 3 patients, a single schisis cavity containing fine strands was present. Some of these strands partially, and others completely, bridged the cavity. In 1 eye of 1 patient, 2 separate schisis cavities with bridging strands were present in the fovea.

Conclusions: Scanning RTA is a noninvasive imaging modality capable of producing optical cross sections that demonstrate the extent and structural details of the foveal schisis in X-linked retinoschisis. Scanning RTA seems to be effective in the detection, characterization, and quantification of foveal schisis.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Child, Preschool
  • Diagnostic Techniques, Ophthalmological*
  • Eye Diseases, Hereditary / genetics
  • Eye Diseases, Hereditary / pathology*
  • Fovea Centralis / pathology
  • Genetic Linkage*
  • Humans
  • Image Processing, Computer-Assisted / instrumentation*
  • Macula Lutea / pathology*
  • Retina / pathology
  • Retinal Degeneration / genetics
  • Retinal Degeneration / pathology*
  • X Chromosome*