MIB-1 labelling index is an independent prognostic marker in primary breast cancer

Br J Cancer. 1998 Aug;78(4):460-5. doi: 10.1038/bjc.1998.515.


The proliferative activity of a tumour is considered to be an important prognostic factor in primary breast cancer. We have investigated the prognostic value of the MIB-1 labelling index in 341 patients with primary breast cancer and compared the results with the S-phase fraction in 220 patients of the same cohort. All patients were treated in one hospital and had a median follow-up of 128 months. No correlation between MIB-1 labelling and S-phase fraction could be demonstrated. MIB-1 had prognostic value for disease-free survival in the whole group of patients (P < 0.001) and in the node-negative subgroup (P < 0.001). In multivariate analysis, MIB-1 was an independent prognostic factor (P = 0.004) besides axillary lymph node status (P = 0.001). In univariate analysis high S-phase fraction was associated with decreased overall survival (P = 0.04); however, not in multivariate analysis. Moreover, S-phase fraction had a borderline prognostic significance for post-relapse survival in multivariate analysis (P= 0.08). Thus, in conclusion, the growth fraction of a tumour as determined by the MIB-1 labelling index is an important prognostic factor in patients with primary breast cancer.

MeSH terms

  • Adult
  • Aged
  • Antibodies, Monoclonal / analysis*
  • Breast Neoplasms / diagnosis*
  • Disease-Free Survival
  • Female
  • Flow Cytometry
  • Humans
  • Immunohistochemistry
  • Ki-67 Antigen / immunology*
  • Middle Aged
  • Multivariate Analysis
  • Prognosis
  • S Phase


  • Antibodies, Monoclonal
  • Ki-67 Antigen