P300 amplitude and antidepressant response to Sudarshan Kriya Yoga (SKY)

J Affect Disord. 1998 Jul;50(1):45-8. doi: 10.1016/s0165-0327(98)00029-9.


Background: There is evidence that Sudarshan Kriya Yoga (SKY) has significant antidepressant effects.

Objective: The present study examined whether pretreatment P300 ERP amplitude predicts antidepressant response to SKY.

Methods: Consenting, drug-free depressed patients (n = 30; dysthymics, 15, melancholics, 15) who received SKY as the sole treatment were assessed clinically at pretreatment, 1 month and 3 months. Auditory P300 was recorded before treatment.

Results: Twenty-two patients responded favourably to SKY. The pretreatment P300 amplitude neither distinguished responders and non-responders nor was associated with differential rates of response.

Discussion: It is concluded that SKY therapy is uniformly effective regardless of the pretreatment P300 amplitude.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Depressive Disorder / physiopathology
  • Depressive Disorder / therapy*
  • Event-Related Potentials, P300*
  • Female
  • Humans
  • Male
  • Yoga*