How is the intracellular fate of the Legionella pneumophila phagosome determined?

Trends Microbiol. 1998 Jul;6(7):253-5. doi: 10.1016/s0966-842x(98)01308-0.


The following pair of articles, the first by Gil Segal and Howard Shuman, and the second by James Kirby and Ralph Isberg (Trends Microbiol. 6, 256-258), explore the genetics and function of the icm/dot genes of Legionella pneumophila. This gene family is implicated in several aspects of virulence and appears to constitute components of a conjugal transfer system that has been adopted to prevent phagosome-lysosome fusion in the host cell and to mediate host cytotoxicity by pore formation. Whether these functions are natural consequences or operate in parallel remains to be discovered.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Genes, Bacterial / physiology
  • Legionella pneumophila / pathogenicity*
  • Phagosomes / microbiology*