Reductive evolution of resident genomes

Trends Microbiol. 1998 Jul;6(7):263-8. doi: 10.1016/s0966-842x(98)01312-2.


Small, asexual populations are expected to accumulate deleterious substitutions and deletions in an irreversible manner, which in the long-term will lead to mutational meltdown and genome decay. Here, we discuss the influence of such reductive processes on the evolution of genomes that replicate within the domain of a host genome.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bacteria / genetics
  • Evolution, Molecular*
  • Genome*
  • Mutation
  • Recombination, Genetic