The ins and outs of peptide signaling

Trends Microbiol. 1998 Jul;6(7):288-94. doi: 10.1016/s0966-842x(98)01313-4.


Many bacteria communicate by secreting and responding to extracellular peptides (pheromones). Some peptide pheromones act via receptors on the cell surface, which are often membrane-bound histidine protein kinases. Other peptide pheromones are transported into the cell by an oligopeptide permease and interact with intracellular receptors to modulate gene expression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Bacteria / cytology*
  • Peptides / physiology*
  • Pheromones / physiology*
  • Signal Transduction / physiology*


  • Peptides
  • Pheromones