Cytochromes P450 in fungi

Mycoses. 1998:41 Suppl 1:32-8. doi: 10.1111/j.1439-0507.1998.tb00581.x.

Abstract

The article gives an overview on the history of the discovery of P450 cytochromes and on their occurrence in nature, especially on their interactions with metabolic pathways in fungi. The significance of the P450 cytochromes in the ergosterol synthesis as well as in the inhibitory mechanisms caused by imidazole and triazole antimycotics is described in detail.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antifungal Agents / chemistry
  • Antifungal Agents / pharmacology
  • Candida albicans / drug effects
  • Candida albicans / enzymology
  • Candida albicans / metabolism
  • Cytochrome P-450 Enzyme System / chemistry
  • Cytochrome P-450 Enzyme System / metabolism*
  • Fungi / drug effects
  • Fungi / enzymology*
  • Fungi / metabolism
  • Humans
  • Models, Molecular
  • Molecular Conformation
  • Molecular Sequence Data
  • Rats
  • Saccharomyces cerevisiae / enzymology
  • Sterols / biosynthesis

Substances

  • Antifungal Agents
  • Sterols
  • Cytochrome P-450 Enzyme System