Restoration of the Mendelian transmission ratio by a deletion in the mouse chromosome 1 HSR

Genet Res. 1998 Apr;71(2):119-25. doi: 10.1017/s0016672398003206.


The house mouse, Mus musculus, harbours a variable cluster of long-range repeats in chromosome 1. As shown in previous studies, some high-copy clusters such as the MUT cluster are cytogenetically apparent as a homogeneously staining region (HSR) and are associated with a distortion of the Mendelian recovery ratio when transmitted by heterozygous females. The effect is caused by a decreased viability of +/+ embryos. It is compensated by maternal or paternal MUT. In this study, a deletion derivative of MUT, MUTdel, shows normal transmission ratios and no compensating capability. In this respect, MUTdel behaves like a wild-type cluster. Hence, both properties--transmission ratio distortion and compensating capability--map to the deleted region. The deletion comprises three-quarters of the MUT HSR and does not extend to the nearest markers adjacent to the HSR.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromosome Deletion*
  • Chromosome Mapping
  • Female
  • Genomic Imprinting
  • Heterozygote
  • Homozygote
  • Mice / genetics*