Family History and Age-Related Maculopathy: The Blue Mountains Eye Study

Aust N Z J Ophthalmol. 1998 Aug;26(3):203-6. doi: 10.1111/j.1442-9071.1998.tb01311.x.


Purpose: To assess the associations between stages of age-related maculopathy (ARM) and reported family history of this eye disease.

Methods: A cross-sectional study of 3654 subjects from a defined geographical area west of Sydney (NSW, Australia) identified subjects with late age-related macular degeneration (AMD) and early ARM from masked detailed grading of retinal photographs. Interviewer-administered questionnaires provided data on family history of ARM. Logistic regression was used to assess associations, adjusting for other known risk factors.

Results: A family history of ARM was significantly associated with both late AMD (odds ratio (OR) 3.92; 95% confidence interval (CI) 1.34-11.46) and early ARM (OR 2.17; 95% CI 1.04-4.55). The association was highest for neovascular AMD.

Conclusions: These findings provide persuasive evidence that a stated family history of ARM is an important risk factor for ARM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Cross-Sectional Studies
  • Family Health*
  • Female
  • Humans
  • Logistic Models
  • Macular Degeneration / epidemiology*
  • Macular Degeneration / genetics
  • Male
  • Middle Aged
  • New South Wales / epidemiology
  • Odds Ratio
  • Risk Factors
  • Surveys and Questionnaires