Serum antioxidant vitamins and risk of lung and stomach cancers in Shenyang, China

Cancer Lett. 1998 Jul 17;129(2):145-9. doi: 10.1016/s0304-3835(98)00103-7.

Abstract

In a hospital-based case control study, we measured serum concentrations of vitamin A, beta-carotene and vitamin E for subjects with cancer (58 cases of lung cancer and 22 cases of stomach cancer) and 63 matched controls in Shenyang, China. Lung cancer patients had significantly (P < 0.01) lower mean serum levels of vitamin A, beta-carotene and vitamin E than controls, while the mean serum level of vitamin E did not differ between stomach cancer patients and the controls. Lower serum levels of vitamin A, vitamin E and beta-carotene were associated with an increased risk of lung cancer. Lower serum levels of vitamin A and beta-carotene were associated with a higher risk of stomach cancer, although the number of cases was small. An increased risk of lung cancer associated with lower serum levels of vitamin A and vitamin E was more evident among heavy smokers than among non-heavy smokers.

MeSH terms

  • Adult
  • Aged
  • Antioxidants / analysis*
  • Case-Control Studies
  • China / epidemiology
  • Female
  • Humans
  • Lung Neoplasms / blood*
  • Lung Neoplasms / epidemiology
  • Male
  • Middle Aged
  • Odds Ratio
  • Risk Factors
  • Smoking / blood
  • Stomach Neoplasms / blood*
  • Stomach Neoplasms / epidemiology
  • Vitamin A / blood
  • Vitamin E / blood
  • beta Carotene / blood

Substances

  • Antioxidants
  • beta Carotene
  • Vitamin A
  • Vitamin E