Amiloride-sensitive Na channels

Curr Opin Cell Biol. 1998 Aug;10(4):443-9. doi: 10.1016/s0955-0674(98)80056-2.


The emerging epithelial Na channel/degenerin family of sodium channels is rapidly expanding, in particular with new members expressed in mammalian neurons and potentially involved in pain transmission. Experimental evidence supports a four-subunit stoichiometry for these channels (although this is still controversial), and basic functional elements (pore and selectivity filter, amiloride binding site, gating) have started to be attributed to specific domains of the protein. Although much remains to be done, in the past year progress has been made in the understanding of several regulatory mechanisms: the control of epithelial Na channel translation by mineralocorticoid hormones, the role of endocytosis and ubiquitination for degradation in the control of the channel density and the role of extracellular proteases.

Publication types

  • Review

MeSH terms

  • Acid Sensing Ion Channels
  • Amiloride*
  • Animals
  • Degenerin Sodium Channels
  • Epithelial Sodium Channels
  • Humans
  • Ion Channels / drug effects
  • Ion Channels / genetics*
  • Nerve Tissue Proteins / drug effects
  • Nerve Tissue Proteins / genetics*
  • Sodium Channels / drug effects
  • Sodium Channels / genetics*


  • ASIC2 protein, human
  • Acid Sensing Ion Channels
  • Degenerin Sodium Channels
  • Epithelial Sodium Channels
  • Ion Channels
  • Nerve Tissue Proteins
  • Sodium Channels
  • Amiloride