Inhibition of icosanoid production in MC/9 mouse mast cells by n-3 polyunsaturated fatty acids isolated from edible marine algae

Biosci Biotechnol Biochem. 1998 Jul;62(7):1412-5. doi: 10.1271/bbb.62.1412.

Abstract

The effects of two polyunsaturated fatty acids, 18:4n-3 and 16:4n-3 purified from the marine algae, Undaria pinnatifida and Ulva pertusa, on icosanoid production in MC/9 mouse mast cells were assessed. Both fatty acids suppressed the production of leukotriene B4 (LTB4), leukotriene C4 (LTC4), and 5-hydroxyeicosatetraenoic acid (5-HETE). The order of the suppressive activity for the two marine algae-derived fatty acids and three other common polyunsaturated fatty acids was as follows; 22:6n-3 = 18:4n-3 = 18:3n-3 > 20:5n-3 = 16:4n-3 for LTB4; 22:6n-3 = 18:4n-3 = 18:3n-3 > 16:4n-3 > 20:5n-3 (no suppression) for LTC4; 22:6n-3 = 18:4n-3 > 18:3n-3 > 20:5n-3 = 16:4n-3 for 5-HETE.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calcimycin / chemistry
  • Chromatography, High Pressure Liquid
  • Eukaryota / chemistry*
  • Fatty Acids, Unsaturated / isolation & purification*
  • Fatty Acids, Unsaturated / pharmacology
  • Hydroxyeicosatetraenoic Acids / analysis*
  • Ionophores / chemistry
  • Leukotriene B4 / analysis*
  • Leukotriene C4 / analysis*
  • Mast Cells / drug effects*
  • Mast Cells / metabolism
  • Mice
  • Plants, Edible

Substances

  • Fatty Acids, Unsaturated
  • Hydroxyeicosatetraenoic Acids
  • Ionophores
  • hexadecatetraenoic acid
  • Leukotriene B4
  • Leukotriene C4
  • Calcimycin
  • 5-hydroxy-6,8,11,14-eicosatetraenoic acid
  • parinaric acid