Abstract
The structure of a new triterpene derivative isolated from Poria cocos was determined to be 3 beta-p-hydroxybenzoyldehydrotumulosic acid by spectral and chemical methods. 3 beta-p-hydroxybenzoyldehydrotumulosic acid showed marked inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)- and arachidonic acid (AA)-induced ear inflammation in mice. The 50% inhibitory doses of 3 beta-p-hydroxybenzoyldehydrotumulosic acid were 0.27 and 1.25 mg per ear on TPA- and AA-induced inflammation, respectively.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Anti-Inflammatory Agents, Non-Steroidal / chemistry*
-
Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
-
Arachidonic Acid
-
Female
-
Inflammation / chemically induced
-
Inflammation / drug therapy
-
Japan
-
Medicine, Chinese Traditional
-
Mice
-
Mice, Inbred ICR
-
Molecular Structure
-
Nuclear Magnetic Resonance, Biomolecular
-
Plants, Medicinal*
-
Tetradecanoylphorbol Acetate
-
Triterpenes / chemistry*
-
Triterpenes / isolation & purification
-
Triterpenes / therapeutic use
Substances
-
4-hydroxybenzoyldehydrotumulosic acid
-
Anti-Inflammatory Agents, Non-Steroidal
-
Triterpenes
-
Arachidonic Acid
-
Tetradecanoylphorbol Acetate