3 beta-p-hydroxybenzoyldehydrotumulosic acid from Poria cocos, and its anti-inflammatory effect

Phytochemistry. 1998 Aug;48(8):1357-60. doi: 10.1016/s0031-9422(97)01063-7.

Abstract

The structure of a new triterpene derivative isolated from Poria cocos was determined to be 3 beta-p-hydroxybenzoyldehydrotumulosic acid by spectral and chemical methods. 3 beta-p-hydroxybenzoyldehydrotumulosic acid showed marked inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)- and arachidonic acid (AA)-induced ear inflammation in mice. The 50% inhibitory doses of 3 beta-p-hydroxybenzoyldehydrotumulosic acid were 0.27 and 1.25 mg per ear on TPA- and AA-induced inflammation, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry*
  • Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
  • Arachidonic Acid
  • Female
  • Inflammation / chemically induced
  • Inflammation / drug therapy
  • Japan
  • Medicine, Chinese Traditional
  • Mice
  • Mice, Inbred ICR
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plants, Medicinal*
  • Tetradecanoylphorbol Acetate
  • Triterpenes / chemistry*
  • Triterpenes / isolation & purification
  • Triterpenes / therapeutic use

Substances

  • 4-hydroxybenzoyldehydrotumulosic acid
  • Anti-Inflammatory Agents, Non-Steroidal
  • Triterpenes
  • Arachidonic Acid
  • Tetradecanoylphorbol Acetate